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Anti-CD59 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-CD59 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD59 Antibody See all CD59 primary antibodies
Description:	Mouse monoclonal (MEM-43) antibody to CD59.
Specificity:	The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues.
Applications:	FC, IP, IHC-P
Reactivity:	Human
Immunogen:	Thymocytes and T lymphocytes.
Host:	Mouse
Clonality:	Monoclonal
Clone:	MEM-43
Isotype:	IgG2a
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Involvement in Disease:	Hemolytic anemia, CD59-mediated, with or without polyneuropathy: An autosomal recessive disorder characterized by infantile onset of chronic hemolysis and a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifested as hypotonia, limb muscle weakness, and hyporeflexia.
Post-Translational Modification:	N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants.
Cellular Location:	Cell membrane. Secreted. Soluble form found in a number of tissues.
Database Links:	Entrez Gene: 966?Human Omim: 107271?Human SwissProt: P13987?Human Unigene: 278573?Human Unigene: 709466?Human Unigene: 710641?Human
Synonyms:	16.3A5 Antibody 1F5 Antibody 1F5 antigen Antibody 20 kDa homologous restriction factor Antibody CD 59 Antibody CD59 Antibody CD59 antigen Antibody CD59 antigen complement regulatory protein Antibody CD59 antigen p18 20 Antibody CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344) Antibody CD59 glycoprotein Antibody CD59 molecule Antibody CD59 molecule complement regulatory protein Antibody Cd59a Antibody CD59_HUMAN Antibody CD_antigen=CD59 Antibody Complement regulatory protein Antibody EJ16 Antibody EJ30 Antibody EL32 Antibody FLJ38134 Antibody FLJ92039 Antibody G344 Antibody HRF 20 Antibody HRF-20 Antibody HRF20 Antibody Human leukocyte antigen MIC11 Antibody Ly 6 like protein Antibody Lymphocytic antigen CD59/MEM43 Antibody MAC inhibitory protein Antibody MAC IP Antibody MAC-inhibitory protein Antibody MAC-IP Antibody MACIF Antibody MACIP Antibody MEM43 Antibody MEM43 antigen Antibody Membrane attack complex (MAC) inhibition factor Antibody Membrane attack complex inhibition factor Antibody Membrane inhibitor of reactive lysis Antibody MGC2354 Antibody MIC11 Antibody MIN1 Antibody MIN2 Antibody MIN3 Antibody MIRL Antibody MSK21 Antibody p18 20 Antibody Protectin Antibody Surface antigen recognized by monoclonal Antibody T cell activating protein Antibody
Information:	Target information shown above is from the UniProt Consortium.