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Anti-mTOR (S2442) Antibody

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Anti-mTOR (S2442) Antibody

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Overview

Name:	Anti-mTOR (S2442) Antibody See all mTOR primary antibodies
Description:	Rabbit polyclonal antibody to mTOR (S2442)
Specificity:	mTOR (S2442) pAb detects endogenous levels of mTOR protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 2430-2480 of Human mTOR.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 289 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'. Regulates osteoclastogensis by adjusting the expression of CEBPB isoforms (By similarity).
Tissue Specificity:	Expressed in numerous tissues, with highest levels in testis.
Involvement in Disease:	Smith-Kingsmore syndrome: An autosomal dominant syndrome characterized by intellectual disability, macrocephaly, seizures, umbilical hernia, and facial dysmorphic features.
Sequence Similarities:	Belongs to the PI3/PI4-kinase family.
Post-Translational Modification:	Autophosphorylates when part of mTORC1 or mTORC2. Phosphorylation at Ser-1261, Ser-2159 and Thr-2164 promotes autophosphorylation. Phosphorylation in the kinase domain modulates the interactions of MTOR with RPTOR and PRAS40 and leads to increased intrinsic mTORC1 kinase activity. Phosphorylation at Thr-2173 in the ATP-binding region by AKT1 strongly reduces kinase activity.
Cellular Location:	Endoplasmic reticulum membrane. Golgi apparatus membrane. Mitochondrion outer membrane. Lysosome. Cytoplasm. Nucleus > PML body. Microsome membrane. Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137).
Database Links:	Entrez Gene: 2475?Human Entrez Gene: 56717?Mouse Entrez Gene: 56718?Rat Omim: 601231?Human SwissProt: P42345?Human SwissProt: Q9JLN9?Mouse SwissProt: P42346?Rat Unigene: 338207?Human Unigene: 21158?Mouse Unigene: 11008?Rat
Synonyms:	dJ576K7.1 (FK506 binding protein 12 rapamycin associated protein 1) Antibody FK506 binding protein 12 rapamycin associated protein 1 Antibody FK506 binding protein 12 rapamycin associated protein 2 Antibody FK506 binding protein 12 rapamycin complex associated protein 1 Antibody FK506-binding protein 12-rapamycin complex-associated protein 1 Antibody FKBP rapamycin associated protein Antibody FKBP12 rapamycin complex associated protein Antibody FKBP12-rapamycin complex-associated protein Antibody FKBP12-rapamycin complex-associated protein 1 Antibody FLJ44809 Antibody FRAP Antibody FRAP1 Antibody FRAP2 Antibody Mammalian target of rapamycin Antibody Mechanistic target of rapamycin Antibody mTOR Antibody MTOR_HUMAN Antibody OTTHUMP00000001983 Antibody RAFT1 Antibody Rapamycin and FKBP12 target 1 Antibody Rapamycin associated protein FRAP2 Antibody Rapamycin target protein Antibody Rapamycin target protein 1 Antibody RAPT1 Antibody Serine/threonine-protein kinase mTOR Antibody
Information:	Target information shown above is from the UniProt Consortium.