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Anti-PCNA (I88) Antibody

品牌：Antibodies

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規(guī)格：50μl

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Anti-PCNA (I88) Antibody

商品詳情參考文獻相關資料

Overview

Name:	Anti-PCNA (I88) Antibody See all PCNA primary antibodies
Description:	Rabbit polyclonal antibody to PCNA (I88)
Specificity:	PCNA (I88) pAb detects endogenous levels of PCNA protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 51-100 of Human PCNA.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 29, 36 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.
Involvement in Disease:	Ataxia-telangiectasia-like disorder 2: A neurodegenerative disorder due to defects in DNA excision repair. ATLD2 is characterized by developmental delay, ataxia, sensorineural hearing loss, short stature, cutaneous and ocular telangiectasia, and photosensitivity.
Sequence Similarities:	Belongs to the PCNA family.
Post-Translational Modification:	Phosphorylated. Phosphorylation at Tyr-211 by EGFR stabilizes chromatin-associated PCNA.
Cellular Location:	Nucleus. Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Database Links:	Entrez Gene: 5111?Human Entrez Gene: 18538?Mouse Entrez Gene: 25737?Rat Omim: 176740?Human SwissProt: P12004?Human SwissProt: P17918?Mouse SwissProt: P04961?Rat Unigene: 147433?Human Unigene: 728886?Human Unigene: 7141?Mouse Unigene: 223?Rat
Synonyms:	ATLD2 Antibody cb16 Antibody Cyclin Antibody DNA polymerase delta auxiliary protein Antibody etID36690.10 Antibody fa28e03 Antibody fb36g03 Antibody HGCN8729 Antibody MGC8367 Antibody Mutagen-sensitive 209 protein Antibody OTTHUMP00000030189 Antibody OTTHUMP00000030190 Antibody PCNA Antibody Pcna/cyclin Antibody PCNAR Antibody PCNA_HUMAN Antibody Polymerase delta accessory protein Antibody Proliferating cell nuclear antigen Antibody wu:fa28e03 Antibody wu:fb36g03 Antibody
Information:	Target information shown above is from the UniProt Consortium.