The antibody B-A38 recognizes CD138 (syndecan 1), a 65-70 kDa heparan sulfate proteoglycan expressed mainly in the epidermis and plasma cells, but also in growth factor-stimulated lymphocytes.
Applications:
FC, IHC
Reactivity:
Human
Immunogen:
U266 human peripheral blood myeloma cell line.
Host:
Mouse
Clonality:
Monoclonal
Clone:
B-A38
Isotype:
IgG1
Conjugate:
Unconjugated
Purification:
Protein A chromatography.
Concentration:
1 mg/ml
Purity:
> 95% (by SDS-PAGE)
Product Form:
Liquid
Formulation:
Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised).
Storage:
Store at 2-8°C.
Target
Function:
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Sequence Similarities:
Belongs to the syndecan proteoglycan family.
Post-Translational Modification:
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Cellular Location:
Membrane. Secreted. Secreted > Exosome.
Shedding of the ectodomain produces a soluble form.