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Anti-CD63 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-CD63 Antibody

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Overview

Name:	Anti-CD63 Antibody See all CD63 primary antibodies
Description:	Mouse monoclonal (MEM-259) antibody to CD63.
Specificity:	The antibody MEM-259 reacts with CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.
Applications:	FC, IP, IHC-P, ICC
Reactivity:	Human
Immunogen:	HPB-ALL T cell line.
Host:	Mouse
Clonality:	Monoclonal
Clone:	MEM-259
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Tissue Specificity:	Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Sequence Similarities:	Belongs to the tetraspanin (TM4SF) family.
Post-Translational Modification:	Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Cellular Location:	Cell membrane. Lysosome membrane. Late endosome membrane. Endosome > Multivesicular body. Melanosome. Secreted > Exosome. Cell surface. Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Database Links:	Entrez Gene: 967?Human Omim: 155740?Human SwissProt: P08962?Human Unigene: 445570?Human
Synonyms:	Lysosomal associated membrane protein 3 Antibody CD 63 Antibody CD63 Antibody CD63 antigen Antibody CD63 antigen (melanoma 1 antigen) Antibody CD63 antigen melanoma 1 antigen Antibody CD63 molecule Antibody CD63_HUMAN Antibody gp55 Antibody Granulophysin Antibody LAMP 3 Antibody LAMP-3 Antibody LAMP3 Antibody LIMP Antibody Lysosomal-associated membrane protein 3 Antibody Lysosome associated membrane glycoprotein 3 Antibody Mast cell antigen AD1 Antibody ME491 Antibody Melanoma 1 antigen Antibody Melanoma associated antigen ME491 Antibody Melanoma associated antigen MLA1 Antibody Melanoma-associated antigen ME491 Antibody MGC72893 Antibody MLA 1 Antibody MLA1 Antibody NGA Antibody Ocular melanoma associated antigen Antibody Ocular melanoma-associated antigen Antibody OMA81H Antibody PTLGP40 Antibody Tetraspanin 30 Antibody Tetraspanin-30 Antibody Tspan 30 Antibody Tspan-30 Antibody TSPAN30 Antibody
Information:	Target information shown above is from the UniProt Consortium.