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Anti-CD11b Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-CD11b Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-CD11b Antibody See all CD11b primary antibodies
Description:	Rat monoclonal (M1/70) antibody to CD11b.
Specificity:	The rat monoclonal antibody M1/70 detects CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions.
Applications:	FC, IP, IHC-Fr, FUNC
Reactivity:	Human, Non-Human Primates, Mouse, Rabbit
Immunogen:	B10 mouse spleen cells enriched for T cells.
Host:	Rat
Clonality:	Monoclonal
Clone:	M1/70
Isotype:	IgG2b
Conjugate:	Unconjugated
Purification:	Protein G chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Storage:	Store at 2-8°C.

Target

Function:	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:8986723, PubMed:9382884, PubMed:9862668). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (PubMed:8986723). May play a role in mast cell development (PubMed:9862668).
Tissue Specificity:	Predominantly expressed in monocytes and granulocytes (PubMed:3887182, PubMed:8986723). Expressed in a subset of peritoneal mast cells (PubMed:9862668).
Sequence Similarities:	Belongs to the integrin alpha chain family.
Cellular Location:	Cell membrane. Membrane raft.
Database Links:	Entrez Gene: 3684?Human Entrez Gene: 16409?Mouse Entrez Gene: 100351865?Rabbit Omim: 120980?Human SwissProt: P11215?Human SwissProt: P05555?Mouse Unigene: 172631?Human Unigene: 262106?Mouse
Synonyms:	antigen CD11b (p170) Antibody Antigen CD11b p170 Antibody CD11 antigen like family member B Antibody CD11 antigen-like family member B Antibody CD11b Antibody CD11b/CD18 Antibody CD49d Antibody Cell surface glycoprotein MAC-1 subunit alpha Antibody Complement component 3 receptor 3 subunit Antibody Complement Component Receptor 3 Alpha Antibody Complement receptor type 3, alpha subunit Antibody CR 3 alpha chain Antibody CR 3 alpha chain (CR3A) Antibody CR-3 alpha chain Antibody CR3 Antibody CR3A Antibody F730045J24Rik Antibody Integrin Alpha M Antibody Integrin alpha M chain Antibody Integrin alpha-M Antibody Integrin beta 2 alpha subunit Antibody Integrin subunit alpha M Antibody integrin, alpha M (complement component 3 receptor 3 subunit) Antibody ITAM_HUMAN Antibody ITGAM Antibody Leukocyte adhesion receptor MO1 Antibody Ly-40 Antibody MAC 1 Antibody Mac-1a Antibody MAC1 Antibody Mac1, alpha subunit Antibody MAC1A Antibody Macrophage antigen alpha polypeptide Antibody MGC117044 Antibody Mo1, alpha subunit Antibody MO1A Antibody Neutrophil adherence receptor Antibody Neutrophil adherence receptor alpha M subunit Antibody SLEB6 Antibody
Information:	Target information shown above is from the UniProt Consortium.