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Anti-FOXL2 Antibody

品牌：Antibodies

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規(guī)格：100μg

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Anti-FOXL2 Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-FOXL2 Antibody See all FOXL2 primary antibodies
Description:	Goat polyclonal antibody to FOXL2.
Applications:	ELISA, WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to Human FOXL2 (C terminal).
Sequence:	C-DSKTGALHSRLDL
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.
Tissue Specificity:	Expressed in the mesenchyme of developing eyelids. Expressed in ovaries throughout development and *****hood, localized to the undifferentiated granulosa cells in small and medium follicles as well as cumulus cells of preovulatory follicles. Expressed in the pituitary.
Post-Translational Modification:	Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
Cellular Location:	Nucleus.
Database Links:	Entrez Gene: 668?Human Entrez Gene: 26927?Mouse Omim: 605597?Human SwissProt: P58012?Human SwissProt: O88470?Mouse Unigene: 289292?Human Unigene: 151239?Mouse
Synonyms:	Blepharophimosis Antibody Blepharophimosis epicanthus inversus and ptosis Antibody Blepharophimosis epicanthus inversus and ptosis 1 Antibody BPES Antibody BPES 1 Antibody BPES1 Antibody Epicanthus inversus and ptosis 1 Antibody Forkhead box L2 Antibody Forkhead box protein L2 Antibody Forkhead transcription factor FOXL2 Antibody FOX L2 Antibody FOXL 2 Antibody FOXL2 Antibody FOXL2_HUMAN Antibody PFRK Antibody PINTO Antibody PITUITARY FORKHEAD FACTOR Antibody POF 3 Antibody POF3 Antibody
Information:	Target information shown above is from the UniProt Consortium.