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Anti-MMP-2 (L638) Antibody

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Anti-MMP-2 (L638) Antibody

商品詳情參考文獻(xiàn) 相關(guān)資料

Overview

Name:	Anti-MMP-2 (L638) Antibody See all MMP-2 primary antibodies
Description:	Rabbit polyclonal antibody to MMP-2 (L638)
Specificity:	MMP-2 (L638) pAb detects endogenous levels of MMP-2 protein.
Applications:	WB, IHC, IF
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 601-650 of Human MMP-2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 74 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-\|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
Tissue Specificity:	Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate.
Involvement in Disease:	Multicentric osteolysis, nodulosis, and arthropathy: An autosomal recessive syndrome characterized by severe multicentric osteolysis with predominant involvement of the hands and feet. Additional features include coarse face, corneal opacities, patches of thickened, hyperpigmented skin, hypertrichosis and gum hypertrophy.
Sequence Similarities:	Belongs to the peptidase M10A family.
Post-Translational Modification:	Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro.
Cellular Location:	Secreted > Extracellular space > Extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
Database Links:	Entrez Gene: 4313?Human Entrez Gene: 17390?Mouse Entrez Gene: 81686?Rat Omim: 120360?Human SwissProt: P08253?Human SwissProt: P33434?Mouse SwissProt: P33436?Rat Unigene: 513617?Human Unigene: 29564?Mouse Unigene: 6422?Rat
Synonyms:	72 kDa gelatinase Antibody 72 kDa type IV collagenase Antibody 72kD type IV collagenase Antibody CLG 4 Antibody CLG 4A Antibody CLG4 Antibody CLG4A Antibody Collagenase Type 4 alpha Antibody Collagenase type IV A Antibody EC 3.4.24.24 Antibody Gelatinase A Antibody Gelatinase alpha Antibody Gelatinase neutrophil Antibody Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Antibody Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase Antibody Matrix metalloproteinase 2 Antibody Matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase) Antibody Matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Antibody Matrix metalloproteinase II Antibody Matrix metalloproteinase-2 Antibody MMP 2 Antibody MMP II Antibody MMP-2 Antibody MMP2 Antibody MMP2_HUMAN Antibody MONA Antibody Neutrophil gelatinase Antibody PEX Antibody TBE 1 Antibody TBE-1 Antibody
Information:	Target information shown above is from the UniProt Consortium.