產品介紹
Quidel Guinea Pig Serum Complement
A119 / A121
Two sizes: 2.0 mL and 5.0 mL
> 40 mg protein/mL
> 100 CH50 units/mL > 50 AH50 units/mL
At or below –70°C
For Research Use Only. Not for use in diagnostic procedures.
Guinea pig serum characterized for both classical and alternative pathway activity. Guinea pig serum complement is suitable for in vitro experiments relating to complement activation. It has been widely used in biomaterials research and pharmaceutical development. It is ideal for experiments and assays for which a high level of in vitro complement activity is necessary or a low level of complement activation fragments is required.
This product is intended for use in an experimental setting specifically for monitoring in vitro complement activation. It is therefore appropriate for use in biocompatibility experiments including drug development, biomaterials testing and other applications where the effects of complement need to be monitored. This product contains no EDTA.
Quidel guinea pig serum complement is a uniform pool of guinea pig serum that has been characterized for both classical and alternative pathway activity. Guinea pig serum has been in use from the beginning of the twentieth century to the present for the study of complement activity and its relationship to immunity. 1-4 The discovery of guinea pigs deficient in specific complement fragments has furthered this research. Guinea pig serum is recommended by both the U.S. and European Pharmacopoeia for testing the anticomplementary activity of immunoglobulin
Guinea pig serum complement is suitable for in vitro experiments relating to complement activation. It has been widely used in biomaterials research and pharmaceutical development. It is ideal for experiments and assays for which a high level of in vitro complement activity is necessary or a low level of complement activation fragments is required.
This product should be stored at or below –70°C. When needed, it should be thawed rapidly at 37°C and immediately placed on ice until use. Any remaining sera should be aliquotted into polypropylene tubes in a convenient volume and refrozen at –70°C or below. Avoid repeated freeze thaw. Storage at temperatures warmer than –70°C is not recommended.
Moore, H.D. Complementary and opsonic functions in their relation to immunity: A study of the serum of guinea-pigs naturally deficient in complement. J. Immunol 4:425-441, 1919.
Hyde R.R., Parsons E.I. Quantitative interdependence of sensitizer and complement in hemolysis. Am. J. Epidemiol. 7(1):11-21, 1927.
Muller F., Segerling M. A factor in guinea-pig serum with accelerating effect on immune immobilization of Treponema pallidum (IAF): Isolation, purification and differentiation from the known haemolytic complement components and from lysozyme. Immunology 27:33-41, 1974.
Wooley, R.E. et al. Comparison of chicken plasma and guinea pig serum in a quantitative microtiter method of determining microbial complement resistance. Avian Diseases 35(4):897-900, 1991.
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