最近最新的日本中文MV_麻豆出品视频在线_超pen个人视频97_国产精品第一国产精品_国产香蕉片_免费看麻豆文化传媒_奶大灬舒服灬太大了一进一出_人妻激情偷乱一区二区三区

≥ 95% by SDS PAGE

Borate Buffered Saline (pH 8.4 ± 0.2)

Human 

≤ 30 Days 2-8?C 

> 30 Days ≤ –20?C

For Research Use Only. Not for use in Diagnostic Procedures

A murine monoclonal antibody to an epitope Factor I.

This monoclonal antibody was raised against purified human Factor I. It does not inhibit function of Factor I.

Quidel's Factor I monoclonal antibody #2 has been used in a variety of experimental techniques including EIA

Factor I is one of the complement proteins which is unique to the Alternative Pathway. It is a 88 kD glycoprotein composed of heavy (50 kD) and light (38 kD) chains linked by disulphide bonds. Factor I is a highly specific serine protease which cleaves the alpha chain of C3b and C4b leading to the formation of iC3b and C3f, followed by C3c and C3d,g. It does not function effectively without a cofactor, such as Factor H, CR1, MCP or CR2. The concentration of Factor I in human serum/plasma is ~34 μg/ml. 

The Alternative Complement Pathway provides innate protection against microbial agents in the absence of specific antibodies. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharaides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells, and cancer cells. In autoimmune diseases, the Alternative Complement Pathway may contribute directly to tissue damage

The specificity of the monoclonal antibody was established by ELISA and RIA. The antibody was shown to bind highly purified Factor I. By RIA, the antibody immunoprecipitates radiolabeled Factor I sing protein A-bearing bacteria to capture the immune complex. The antibody does not inhibit the cleavage of C3b to iC3b in the presence of Factor H and Factor I.