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產品介紹
Monoclonal Antibody to Human Factor B (Ba)
A225
100 μL
IgG1k
≥ 95% by SDS PAGE
None tested
≤ 30 Days 2-8?C
> 30 Days ≤ –20?C
For Research Use Only. Not for use in diagnostic procedures
Factor B is one of the complement proteins which is unique to the Alternative Pathway. It is a single-chain glycoprotein with a molecular weight of approximately 98 kD. The concentration of Factor B in human serum/plasma is ~200 μg/ml.
The Alternative Complement Pathway provides innate protection against microbial agents in the absence of specific antibodies. The activation of this complement pathway can be triggered by a variety of substances, including microbial polysaccharaides or lipids, gram-negative bacterial lipopolysaccharides, and surface determinants present on some viruses, parasites, virally infected mammalian cells, and cancer cells. In autoimmune diseases, the Alternative Complement Pathway may contribute directly to tissue damage.
The specificity of the monoclonal antibody for the Factor B (Ba) protein was established by ELISA. The antibody was shown to bind highly purified Factor B and its Ba fragment, but not to the Bb fragment. The antibody binds a non-neoantigen in the Ba domain of native Factor B, since highly purified, functionally active Factor B and normal human plasma blocked binding of the antibody to both Factor B and Ba fragments coated in microtiter wells. Zymosan activated human serum was not more effective than the corresponding non-activated plasma in blocking the binding of this antibody.
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