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PBS

At or below –70°C

 Purified human complement component C8. Complement component C8 is unique to the terminal complement pathway. It is composed of three protein chains (α 65 kD; ? 65 kD; Γ 22 kD) and is present in plasma at approximately 55 mg/L. Together with the other proteins of the terminal pathway, C8 forms the membrane attack complex or MAC.

All Quidel complement components are tested for functional activity in a standard lytic or applicable functional assay and for biochemical purity by SDS-polyacrylamide gel electrophoresis. Please refer to the Certificate of Analysis for lot specific information on functional titer.

 Nicholson-Weller, Butko, P, Wessels, M. Role of Complement Component C1q in IgG independent Opsonophagocytosis of Group B Streptococus, J. Immunol 163:2761-2768, 1999.

Koski, C., Dashell, S. Sublytic terminal complement complex decreases Po gene expression in schwan cells, J Neurochem 73(6):2321-2330, 1999.

Liu, C., et al. Interaction between the terminal complement pathway complex C5b-7 and anionic phospholipids, Blood 93(7)2291-2301, 1999.

 For Research Use Only. Not for use in diagnostic procedures.