Article no.: T-500-10
Description
Transthyretin (TTR), formerly known as Prealbumin, is in vivo involved in the binding and transportation of the Thyroxin hormone and retinol-binding protein. Mutations in TTR are associated with familial amyloidotic polyneuropathy (FAP) which is a fatal disease characterized by amyloid depositions found in visceral organs including the heart, liver, and kidney. The wild type form of TTR is associated with a late onset amyloidosis denoted senile systemic amyloidosis, affecting around 25% of the population above 80 years of age with depositions mainly found in the heart.
Amount
1mg
Format
Lyophilized
Molecular Weight
13760 Da
Sequence
GPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKV EIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Purity
95% by Chromatography and SDS-PAGE
Counter Ion
Ammonium Carbonate
Solubility
The lyophilized protein is readily soluble in PBS pH 7.4.
Storage
Store at -20°C upon arrival.
Source
Protein expressed in Escherichia coli.
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